Telefonica is working through a strategic plan that will pave the way for O2 float

2016 (May) European Commission blocks Three purchase of O2 Telefonica is working through a strategic plan that will pave the way for O2 float Sunday 29 January 2017 3:01 pm A £10bn sale of O2 to competitor Three was blocked by the European Commission last May.  1985 Cellnet established – joint venture (60:40) between BT and Securicor Read more: O2 chief executive Ronan Dunne leaving the companyTelefonica stepped up plans to spin O2 in the wake of the news, appointing Barclays to lead a raft of investment banks to run the deal.The listing was put on ice in October, as the O2 float fell victim along with a host of other major names to concerns over market conditions. whatsapp by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeMisterStoryWoman files for divorce after seeing this photoMisterStoryWarped SpeedCan You Name More State Capitals Than A 5th Grader? Find Out Now!Warped SpeedMaternity WeekA Letter From The Devil Written By A Possessed Nun In 1676 Has Been TranslatedMaternity WeekLiver Health1 Bite of This Melts Belly And Arm Fat (Take Before Bed)Liver HealthHealthyGemBaby Has Never Eaten Sugar Or Carbs, Wait Till You See Her TodayHealthyGemFactablePut Baking Soda Around The Base Of A Tomato Plant, Here’s WhyFactable2021 Buicks | Search AdsIntroducing The Head Turning 2021 Buicks!2021 Buicks | Search AdsJournalistatePierce Brosnan’s Wife Lost 120 Pounds – This Is Her NowJournalistateNoteableyJulia Robert’s Daughter Turns 16 And Looks Just Like Her MomNoteabley 2005 Spanish firm Telefonica buys O2 in £18bn deal 2001 BT Cellnet spun-off into separate company 1999 BT buys out Securicor, rebrands as BT Cellnet Oliver Gill 2014 BT in talks to buy either O2 or rival EE, ultimately went for EE 2016 (Oct) Telefonica withdraws listing plans Read more: Fears for London IPO market as Misys and O2 pull 2016 float plansThe division of Telefonica in question – which owns a network of phone masts and undersea cables – is called Telxius and was the subject of a failed float last September.And the reports indicate the Spanish telecoms giant is hoping to flog the business using the proceeds to pay down its bellowing £47bn debt pile.Once complete Telefonica will turn its attentions back to selling subsidiary O2 either through a float or sale.Who owns O2? 2002 BT Cellnet rebranded as O2 2015 Three agrees to buy O2 for £10bn Date Event 2016 (Sept) Telefonica appoints advisers for London listing of O2 whatsapp O2’s owner has set the ball rolling on a strategic plan to clear legacy issues before either floating or selling the British mobile phone operator, according to reports.Singapore’s sovereign wealth fund, GIC, is working with private equity fund CVC to buy a controlling share in Telefonica’s infrastructure division in a deal worth €1.5bn (£1.3bn), the Sunday Times reported.  Share More From Our Partners Astounding Fossil Discovery in California After Man Looks Closelygoodnewsnetwork.orgFlorida woman allegedly crashes children’s birthday party, rapes teennypost.comBrave 7-Year-old Boy Swims an Hour to Rescue His Dad and Little Sistergoodnewsnetwork.orgInside Ashton Kutcher and Mila Kunis’ not-so-average farmhouse estatenypost.comRussell Wilson, AOC among many voicing support for Naomi Osakacbsnews.comNative American Tribe Gets Back Sacred Island Taken 160 Years Agogoodnewsnetwork.orgA ProPublica investigation has caused outrage in the U.S. this weekvaluewalk.comPolice Capture Elusive Tiger Poacher After 20 Years of Pursuing the Huntergoodnewsnetwork.orgBiden received funds from top Russia lobbyist before Nord Stream 2 giveawaynypost.com980-foot skyscraper sways in China, prompting panic and‘The Love Boat’ captain Gavin MacLeod dies at 90nypost.comSupermodel Anne Vyalitsyna claims income drop, pushes for child supportnypost.comUK teen died on school trip after teachers allegedly refused her pleasnypost.comConnecticut man dies after crashing Harley into live bearnypost.comMatt Gaetz swindled by ‘malicious actors’ in $155K boat sale boondogglenypost.comBill Gates reportedly hoped Jeffrey Epstein would help him win a‘Neighbor from hell’ faces new charges after scaring off home buyersnypost.comWhy people are finding dryer sheets in their read more

China hopes to secure trade deal with US ‘as soon as possible’

first_imgMonday 9 December 2019 7:50 am whatsapp by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeDaily FunnyFemale Athlete Fails You Can’t Look Away FromDaily FunnyNoteableyJulia Robert’s Daughter Turns 16 And Looks Just Like Her MomNoteableyzenherald.comDolly Finally Took Off Her Wig, Fans Gaspedzenherald.comPast Factory4 Sisters Take The Same Picture For 40 Years. Don’t Cry When You See The Last One!Past FactoryFinanceChatterViewers Had To Look Away When This Happened On Live TVFinanceChatterMisterStoryWoman files for divorce after seeing this photoMisterStoryNinjaJournalistMichael Jordan’s Divorce Settlement Has Finally Been Revealed.NinjaJournalistBetterBe20 Stunning Female AthletesBetterBebonvoyaged.comThese Celebs Are Complete Jerks In Real “On the question of China-US trade talks and negotiations, we wish that both sides can, on the foundation of equality and mutual respect, push forward negotiations, and in consideration of each others’ core interests, reach an agreement that satisfies all sides as soon as possible,” Ren said. James Warrington (Getty Images) Read more: FTSE 100 opens higher as China tariff waiver raises hopes of trade truce Share The world’s two largest economies are holding discussions over a so-called phase one trade deal as they look to bring a nearly 18-month long dispute to an end. whatsappcenter_img US President Donald Trump has demanded that China commit to specific minimum purchases of US agricultural products, among other concessions on intellectual property rights, currency and access to China’s financial services markets. China said it hopes to secure a trade deal with the US “as soon as possible”, raising hopes of a breakthrough ahead of a fresh round of intense negotiations this week. Assistant Commerce Minister Ren Hongbin told reporters this morning that Beijing hopes to reach a trade agreement with the US that will satisfy both sides. Read more: Global growth to pick up next year despite US and China slowdowns, says report China last week waived tariffs on some soybean and pork shipments from the US in a sign of a potential easing of tensions. However, it is not clear whether a full agreement can be reached in the near term. China has demanded that some of the existing US tariffs imposed on about $375bn (£285bn) worth of its exports be removed, in addition to cancellation of fresh tariffs on some $156bn of its remaining exports to the US, which are due to come into force on 15 December. White House economic adviser Larry Kudlow last week said that the two sides had talked almost daily, but there were currently no plans for face-to-face talks or a signing ceremony between Trump and Chinese President Xi Jinping. China hopes to secure trade deal with US ‘as soon as possible’ More From Our Partners LA news reporter doesn’t seem to recognize actor Mark Currythegrio.comAstounding Fossil Discovery in California After Man Looks Closelygoodnewsnetwork.orgRussell Wilson, AOC among many voicing support for Naomi Osakacbsnews.comKansas coach fired for using N-word toward Black playerthegrio.comNative American Tribe Gets Back Sacred Island Taken 160 Years Agogoodnewsnetwork.orgMan on bail for murder arrested after pet tiger escapes Houston homethegrio.comBrave 7-Year-old Boy Swims an Hour to Rescue His Dad and Little Sistergoodnewsnetwork.orgA ProPublica investigation has caused outrage in the U.S. this weekvaluewalk.comPolice Capture Elusive Tiger Poacher After 20 Years of Pursuing the Huntergoodnewsnetwork.orglast_img read more

New UK-Kenya trade deal to be extended to all of East Africa

first_img New UK-Kenya trade deal to be extended to all of East Africa after threats not to ratify UK-Kenyan trade deal The UK market accounts for 43 per cent of total exports of vegetables from Kenya as well as at least 9 per cent of its cut flowers. In 2019, UK-Kenya trade was worth an estimated £1.4bn. This weekend’s ‘breakthrough’ – as several newspapers in East-Africa called the extension of the deal – followed weeks of threats on both sides of the Sahara not to ratify the deal. UK’s international trade minister Ranil Jayawardena and Kenya’s cabinet secretary for trade, Betty Maina, signed the UK-Kenya trade deal in December in London Also Read: New UK-Kenya trade deal to be extended to all of East Africa after threats not to ratify While it remains unclear that these issues have been fully addressed, cabinet secretary Betty Maina told The EastAfrican newspaper that “the UK is providing Kenya and all its EAC neighbours a secure, long-term and predictable basis for deepening their access to the UK market.” The recently signed trade deal between the UK and Kenya will be extended to Burundi, Uganda, Rwanda, South Sudan and Tanzania, according to multiple media reports in Kenya. The announcement follows weeks of threats by members of the House of Lords as well as Kenyan MPs not to ratify the trade agreement, which was signed in December of last year. In London, the House of Lords said two weeks ago it would need more time to ratify the agreement amid concerns the UK government had not addressed the potential impact of the pact on regional cohesion in the East Africa region. A cartoon that appeared in The EastAfrican newspaper this weekend (source: The EastAfrican) Their main concern evolved around goods exported from the UK to Kenya, saying the types of products that would fall under an agreed clause – that some goods can be shipped into Kenya duty-free for a period of 25 years – had not been specified. UK’s international trade minister Ranil Jayawardena and Kenya’s cabinet secretary for trade, Betty Maina, signed the UK-Kenya trade deal in December in London According to UK government data, the biggest import to the UK from Kenya in 2019 were, coffee and spices, with a market value of around £121m, vegetables at £79m as well as live trees and plants, mostly flowers, for around £54m. Share More From Our Partners Brave 7-Year-old Boy Swims an Hour to Rescue His Dad and Little Sistergoodnewsnetwork.orgA ProPublica investigation has caused outrage in the U.S. this weekvaluewalk.comPolice Capture Elusive Tiger Poacher After 20 Years of Pursuing the Huntergoodnewsnetwork.orgRussell Wilson, AOC among many voicing support for Naomi Osakacbsnews.comAstounding Fossil Discovery in California After Man Looks Closelygoodnewsnetwork.orgFlorida woman allegedly crashes children’s birthday party, rapes teennypost.comNative American Tribe Gets Back Sacred Island Taken 160 Years Agogoodnewsnetwork.orgWhy people are finding dryer sheets in their mailboxesnypost.comBiden received funds from top Russia lobbyist before Nord Stream 2 UK’s international trade minister Ranil Jayawardena and Kenya’s cabinet secretary for trade, Betty Maina, signed the UK-Kenya trade deal in December in London Also Read: New UK-Kenya trade deal to be extended to all of East Africa after threats not to ratify The UK is a major market for British and Kenyan exporters of tea, coffee, flowers and fresh vegetables. Breakthrough after threats The House of Lords accepted a proposal by its International Agreements Committee to postpone ratification by 21 days. The UK-Kenyan Economic Partnership Agreement was signed in London on 8 December by UK’s international trade minister Ranil Jayawardena and Kenya’s cabinet secretary for trade, Betty Maina. Meanwhile, a majority of MPs in Nairobi, Kenya, said late last week that they refused to ratify the economic partnership with the UK as they accused the government of “sneaking in documents that had not been tabled in [the Kenyan] Parliament,” according to newspaper Business Daily Africa this weekend. Michiel Willems The lawmakers reportedly said that, until they are fully aware of the details of the trade arrangements, the agreement cannot come into force. This means that businesses from Kenya, Burundi, Uganda, Rwanda, South Sudan and Tanzania can export and offer their products into the UK on a no-tariff, no-quota basis, once the deal has been ratified. Tags: UK trade Monday 1 March 2021 10:59 am whatsapp The deal provides Kenyan businesses duty-free access to the UK market, aimed at supporting jobs and economic development in Kenya, as well as to avoid disruption to UK businesses as they maintain tariff-free supply routes for Kenya’s high-quality flowers. UK’s international trade minister Ranil Jayawardena and Kenya’s cabinet secretary for trade, Betty Maina, signed the UK-Kenya trade deal in December in London Also Read: New UK-Kenya trade deal to be extended to all of East Africa after threats not to ratify Show Comments ▼ whatsapp According to a report in regional newspaper The East African this weekend, the Economic Partnership Agreement agreed between the UK and Kenya will be open to all EAC member states.last_img read more

Petersburg leaders favor state income tax over sales tax

first_imgSoutheast | State Government | SyndicatedPetersburg leaders favor state income tax over sales taxJuly 25, 2016 by Angela Denning, KFSK Share:Petersburg is seen from the air in this February 2014 photo. The Southeast community’s assembly wants a statewide income tax before a sales tax. (Photo by Ed Schoenfeld/CoastAlaska News)The Petersburg Borough Assembly agrees with the governor — on at least one thing.At a July 18 meeting, members unanimously approved a resolution supporting a state income tax over a state sales tax, issues that Gov. Bill Walker and the legislature have been considering to bring in more revenue.Walker proposed and backed an income tax. He only brought up a sales tax at the request of some lawmakers.Assemblyman Bob Lynn said a state sales tax would hurt smaller communities more.“When you look at the State of Alaska one of the things that you have is a lot of the smaller communities like similar to the size of Petersburg, even smaller, have a sales tax in place, whereas, a lot of your bigger municipalities do not,” Lynn said. “So, what happens is if you put an additional 3 percent or 6 percent from the state on top of what we have, that would put our local sales tax at 9 percent or higher.”Lynn said an income tax would also include visiting workers.“An income tax reaches out to all those, even those who make their income in Alaska but then take that out of state; quite a difference,” he said.Assemblyman Jeigh Stanton-Gregor agreed saying the sales tax hurts poor people the most.“Sales tax is a regressive. And for those of us who don’t know regressive taxes, they hurt those people on the lowest end of the income spectrum the most,” Stanton-Gregor said. “And just on an ethical level I have a problem with that. It doesn’t seem equitable to me.”The next regular meeting for the assembly is Aug. 1 at noon.Share this story:last_img read more

Gun control groups aim their money at states — and the ballot

first_imgFederal Government | Nation & World | PoliticsGun control groups aim their money at states — and the ballotNovember 4, 2016 by Martin Kaste, NPR Share:Gun control has been a minor theme of this year’s presidential election, as Hillary Clinton promises to close “loopholes” in the background checks for gun purchasers, and Donald Trump pledges “unwavering support” for the Second Amendment.The real battle over guns, though, has been waged at the state level this year — with a new emphasis on ballot initiatives.Washington is a prime example. Like many western states, it has a tradition of permissive gun laws; there’s no minimum waiting period to buy a gun, and the state doesn’t even require safety training for people who carry concealed firearms. In 2013, legislation to require criminal background checks for most gun sales died in the state House of Representatives. So in 2014, activists went around the legislature, putting background checks on the state ballot. It passed by a wide margin.This year, similar background check laws are on the ballot in Nevada and Maine; in California, there’s a ballot measure to require background checks for buyers of ammunition.In Washington state, meanwhile, gun control activists are building on their success with another ballot initiative. This one gives courts the ability to take guns away from people deemed to be dangerous to themselves or others. It’s very well-funded, both by local tech billionaires, as well as Everytown for Gun Safety, the national gun control group founded by Michael Bloomberg.And it’s a one-sided fight. There’s been almost no organized opposition and no political spending by the NRA or other gun rights groups.“People are probably sitting back and waiting to see if this passes and then if it does, you’re going to see a lot of legal challenges,” says Dave Workman, an activist journalist with the Second Amendment Foundation, based in Bellevue, Wash.“That may be the strategy, to beat this thing in court, rather than try to fight what seems like a quote-unquote ‘common-sense measure’ at the ballot box,” Workman says.He also acknowledges a new reality for gun rights groups, as they face the power of groups like Everytown for Gun Safety.“I think the gun control people have suddenly discovered that they’ve got a weapon. And that weapon is money,” Workman says.The gun rights groups have plenty of money, too. “Historically, gun rights groups have always outspent their opponents. But now the initiatives have sprung up,” says J.T. Stepleton, a researcher with the National Institute on Money in State Politics. While the NRA has shifted its money into lobbying and independent expenditures for specific candidates, he says the gun control groups are putting more emphasis on ballot questions.“Clearly, the advocates see this as a good change of venue for them,” Stepleton says.Pro-gun groups have put money into opposing the ballot initiatives in Maine, Nevada and California, but they’re not keeping pace with gun control groups. That may be in part because of their strategic decision to spend heavily on behalf of Donald Trump.The NRA still spends millions — but Stepleton says it’s putting that money more into lobbying and independent expenditures for specific candidates. That leaves an opening for the gun control groups, as they focus on ballot initiatives.“This is really taking a page from the marriage equality playbook,” says Shannon Watts, founder of Moms Demand Action for Gun Sense in America, one of the groups under the Everytown for Gun Safety umbrella. She compares their strategy to the decision made by activists for same sex marriage, after they faced defeats in Congress in the 1990s.“[They said,] ‘We’re going to pivot, and go to the states and companies, and we’re going to get them to put laws and policies in place that point Congress and the Supreme Court in the direction that this nation is headed in,’” Watts says. “And that’s exactly what we have done.”Cheryl Stumbo is a gun control activist in Washington, who survived the mass shooting at Seattle’s Jewish Federation in 2006. She’s been heavily involved in the ballot initiatives, and she frames the strategy as one of picking the right battles.“What can we do that’s going to save the most number of lives right now, and what can we win,” she says. “So that we can keep going and create momentum.”Copyright 2016 NPR. To see more, visit this story:last_img read more

Alaska senators veer apart on family separations

first_imgFederal Government | Nation & WorldAlaska senators veer apart on family separationsJune 20, 2018 by Liz Ruskin, Alaska Public Media Share:The U.S. Capitol in Washington, D.C., on March 28, 2017. (Photo by Jeremy Hsieh/KTOO)The separation of families detained at the southern border is dividing Republicans as they try to keep the scenes of despair from becoming a GOP public relations disaster.Alaska’s two senators have staked out distant positions, at least for the short term.Audio Player Up/Down Arrow keys to increase or decrease volume.Almost everyone says it’s bad to take children from their parents, but that’s what’s happened to thousands of children as a result of the administration’s “zero tolerance” policy for unauthorized border crossing.U.S. Sen. Lisa Murkowski and 12 other Republicans signed a letter Tuesday asking Attorney General Jeff Sessions to halt implementation of the zero tolerance policy to keep families together while Congress works out a solution.The letter, spearheaded by Sen. Orrin Hatch, R-Utah, calls the forced separations “inhumane.”But Trump and other Republicans say Congress needs to pass a law to end the separations.Alaska Sen. Dan Sullivan said that was the direction Senate Republicans took in their weekly policy gathering Tuesday.“Literally, almost the entire lunch that I just walked out of was all focused on what is the legislative solution,” Sullivan said.Sullivan agrees families should be kept together.“But you also have to address this other issue that’s related. It’s the ‘catch and release’ policy,” Sullivan said, referring to the previous policy of giving court dates to people claiming asylum and releasing them from federal detention.Asked whether the president should end family separations immediately, Sullivan said if there’s a way to move up the processing of families so their cases can be heard within 20 days, the administration should consider it.Sullivan said he’s interested in a bill by Sen. Ted Cruz, R-Texas, which would authorize new temporary family shelters and double the number of immigration judges, to about 750, to decide claims more quickly.President Donald Trump rejected Tuesday the idea of hiring massive numbers of new immigration judges.“One of them says ‘we want to hire 5,000 more judges.’ I don’t want judges,” Trump said in a speech to small-business owners. “I want border security. I don’t want to try people. I don’t want people coming in.”Senate Majority Leader Mitch McConnell, R-Ky., emerged from the weekly policy lunch saying he wants to pass a targeted bill within days that would keep families together.But that would mean leaving out the trickier issues, like an immigration overhaul and the president’s proposed border wall.And it’s not clear that’s a solution the president will accept.All 47 Senate Democrats, plus two independents who caucus with them, are backing a narrow bill that would prohibit removing children unless they’re being abused or trafficked.Meanwhile, Republicans in the House of Representatives are drafting two separate bills to address broader immigration policy.One is put forth by the party’s hard-liners and the other is a compromise bill aimed at moderates. It’s not clear either has the votes to pass.Trump said earlier in the day he would make changes to their proposals, but Tuesday evening he reportedly said he’d support either House bill.Share this story:last_img read more

More bad news for Tesco bosses as Harris + Hoole makes big loss

first_imgTuesday 2 December 2014 9:10 pm whatsapp Read This NextRicky Schroder Calls Foo Fighters’ Dave Grohl ‘Ignorant Punk’ forThe Wrap’Drake & Josh’ Star Drake Bell Arrested in Ohio on Attempted ChildThe WrapCNN’s Brian Stelter Draws Criticism for Asking Jen Psaki: ‘What Does theThe WrapHarvey Weinstein to Be Extradited to California to Face Sexual AssaultThe WrapDid Donald Trump Wear His Pants Backwards? Kriss Kross Memes Have AlreadyThe WrapPink Floyd’s Roger Waters Denies Zuckerberg’s Request to Use Song in Ad:The Wrap’The View’: Meghan McCain Calls VP Kamala Harris a ‘Moron’ for BorderThe Wrap’Black Widow’ First Reactions: ‘This Is Like the MCU’s Bond Movie’The WrapKatt Williams Explains Why He Believes There ‘Is No Cancel Culture’ inThe Wrap Share COFFEE chain Harris + Hoole, which is part-owned by troubled supermarket giant Tesco, announ­ced a £12.8m pre-tax loss yesterday on filing its annual accounts. The company, which was forced to close six branches earlier this year following disappointing trading figures, said the results represent a period of investment for the fledgling coffee business, and reported sales of £6.6m in the year to 23 February. Harris + Hoole opened 18 new stores over the course of the year, taking the total number to 30. Most are based in the south-east of England, with some inside Tesco superstores and others operating as stand-alone stories. In a statement yesterday, director and part-founder of the chain Nick Tolley said the business will seek to build on its model of high-end artisanal coffee in the year ahead, using its mobile app to encourage customer loyalty. The app, which was introduced in March this year, allows customers to pay for coffee via their phones in-store. Acknowledging the tough marketplace in which Harris + Hoole operates, Tolley added that the company is “well positioned to continue to grow sales and market share”. Earlier this year, Tolley said the company has the full backing of Tesco despite a tough year for the supermarket chain, following a shock £263m hole in its first-half profit report. More bad news for Tesco bosses as Harris + Hoole makes big loss Tags: NULL whatsapp Show Comments ▼ Kate McCannKate McCann is a reporter at City A.M. She covers politics and insurance and can be contacted at [email protected] last_img read more

News / Customs authorities should align with digital TIR, set to hit the road in May

first_img© Björn Wylezich | – TIR plate By Gavin van Marle 11/03/2021 The digitisation of the road freight industry has taken a major step forward after no UN members states raised objections to new amendments to the TIR system allowing digital documentation – known as the eTIR.“None of the 76 contracting parties to the TIR Convention has communicated an objection to the proposals, adopted last year, to amend various provisions introducing new Annex 11 on eTIR,” said the UN Economic Commission for Europe (UNECE), which administers the TIR convention.“eTIR will thus become a reality [on 25 May], opening new applications for the TIR system, in particular in the area of intermodal transport,” it added.Supporters claim the new legislation will make the TIR system more competitive and efficient, “since all customs authorities involved in an eTIR transport along a given itinerary (customs en route and destination) will be informed in advance, electronically and in seconds, through the dispatch of so-called advance TIR data by a TIR transporter, about an upcoming TIR declaration”.UNECE executive secretary Olga Algayerova said: “I invite all contracting parties to the TIR Convention to start implementing the interconnection of their national customs systems with the eTIR international system as soon as possible, to make the most of its enhanced efficiency and security.”Umberto de Pretto, secretary general of the International Road Transport Union (IRU), added: “This key milestone shows widespread support for transport digitalisation.“IRU and our members will continue working with governments to fully implement eTIR to further smooth border crossings, reduce transport times, boost trade and increase security, especially now, during the pandemic.”And the adoption of the eTIR could provide relief to hauliers operating between the EU and UK, with the IRU arguing that “accredited TIR hauliers in the EU, UK and beyond can use this tried and proven system to easily complete customs procedures”.It noted that in February, the Polish Association of International Road Transporters (ZMPD) and Polish haulier Sachs Trans organised the shipment of high-value medical goods from Poland to the UK under the TIR system.“TIR works across borders all over the world and can make a real difference to companies struggling with the new EU/UK customs border,” said Mr de Pretto.The UNECE also revealed that some 48 contracting parties out of 76 had “expressed interest in initiating discussions/projects on the interconnection of their national customs systems with the eTIR international system”.They are Armenia, Azerbaijan, Georgia, India, Iran, Israel, Lebanon, Montenegro, Morocco, Pakistan, Qatar, Republic of Moldova, Tunisia, Turkey, Ukraine, Uzbekistan, the 27 EU member states and the Russian Federation, which has requested the secretariat to start working on a proof of concept for the five member states of the Eurasian Economic Union.The UNECE also noted that the use of eTIR would be compliant with the various border control measures to limit the spread of coronavirus “by keeping drivers and customs officers safe and healthy, since it provides seamless, paperless and therefore contactless, border crossing operations”.last_img read more

Delays in adding new newborn screening tests harm babies, families

first_img National uptake of a newborn screening test for cystic fibrosis198220062014020406080100YearPercent of newborns screenedYearPercent uptake19821. uptake of a newborn screening test for cystic fibrosis About the Authors Reprints By Robert Moy, Seamus Levine-Wilkinson, and Joseph Sterk April 30, 2018 Reprints Developing a reliable, robust, and economically viable screening test is a long haul. Once a test becomes available, a nomination package is submitted to the Advisory Committee on Heritable Disorders in Newborns and Children, which is part of the federal Department of Health and Human Services. This committee, made up of pediatricians, genetics experts, and others, determines if there is sufficient evidence to convene a group of outside experts to evaluate whether the new test meets the criteria for inclusion in the Recommended Uniform Screening Panel. If this group approves the new test, it is then up to the HHS secretary to make a final decision on whether it should be included in the panel.A new screening test that survives this process still has a long way to go before being implemented: disease advocacy organizations, affected families, their physicians, and biopharmaceutical companies must then lobby individual states to include the test in its newborn screening panel. Our research indicates that it typically takes 10 years or more before a new screening test reaches all U.S. newborns.Take the example of cystic fibrosis, a well-known genetic disease that can lead to early death from respiratory failure. It was the first disorder proven to arise from mutations in a single gene, called CFTR. Colorado was the first state to add screening for cystic fibrosis, in 1982, but it wasn’t until 2014 that all U.S. newborns were tested for it (see the chart below). During this 32-year period, thousands of children born with cystic fibrosis were not diagnosed in a timely manner and missed early-life interventions that could have mitigated the complex respiratory, growth, and digestive issues associated with it. Despite the importance of these programs, little comprehensive data on their adoption is available because they are managed at the state level. As biopharmaceutical strategists and a former diagnostics executive, we help companies think through the realities of addressing rare and genetic diseases, including understanding how many patients there are and how they are diagnosed. This prompted us to spend some time investigating newborn screening programs. Although we are largely inured to the structural inefficiencies that plague the U.S. health care system, we were dismayed to discover that it can take years from the time a new screening test becomes available to its adoption in all 50 states. @Howlinghamster This toddler with a rare disease got a life-changing treatment. Why can’t all kids? Joseph Sterk [email protected] Individuals with genetic diseases often face an excruciatingly long diagnostic odyssey. Between the time they first experience symptoms and the time they get a definitive diagnosis, some see the disease progress, others suffer irreversible damage, and many may experience significantly decreased quality of life. By identifying some of these diseases very early in life, newborn screening programs save and improve the lives of thousands of infants in the U.S. every year.State-run screening programs can identify many affected individuals at birth, but their fragmented nature and delays in incorporating new tests results in unnecessary suffering for children born with addressable disorders who go undiagnosed because they are born in states that move slowly to adopt screening tests.Newborn screening programs, which can reach virtually all of the 4 million babies born in the U.S. each year, currently monitor for 60 rare and genetic conditions. An abnormal test result triggers a confirmatory test, such as gene sequencing, and potentially leads to a full diagnosis within two weeks.advertisement National uptake of a screening test for severe combined immunodeficiency disorder20082009201020112012201320142015201620172018020406080100YearPercent of newborns screenedYearPercent of births screened2008220094201022201125201244201356201471201579201686201795201896National uptake of a screening test for severe combined immunodeficiency disorder [email protected] Patrick Skerrett/STAT Source: CLARION HEALTHCARE. Note: Severe combined immunodeficiency was added to the Recommended Uniform Screening Panel in 2010. Families affected by rare diseases that aren’t included in newborn screening panels face even greater hurdles as they search for a diagnosis. Spinal muscular atrophy, a disorder affecting nerves that control muscles, is the leading genetic cause of death for infants. Some families are willing to pay several hundred dollars for screening. Unfortunately, many affected families do not have the resources, or the awareness, to seek out testing on their own.That affected families must figure this out for themselves underscores a basic problem with our current approach to newborn screening. It is inefficient, and arguably cruel, to place responsibility for advancing screening tests on affected families and their physicians who are grappling with the hard realities of caring for children with often devastating and poorly understood diseases.We offer three suggestions for helping the health care community improve the newborn screening systems in place and accelerate the nationwide adoption of new tests.Engage interested parties early. Raising awareness of a disease that could be included in the newborn screening panel among families, physicians, and advocacy groups is an important place to start. Getting them to promote the test within state legislatures and health departments is another important step. If advocacy does not exist at the national level, launching or backing an umbrella organization of local groups can help create a presence before Congress and HHS. Blood samples collected from a newborn to screen for serious inherited diseases. Michael Conroy/AP Patrick Skerrett/STAT Source: CLARION HEALTHCARE. Note: The Recommended Uniform Screening Panel was created in 2006; cystic fibrosis was one of the tests included. The long road to nationwide adoption of newborn screening for cystic fibrosis sadly appears to be typical. Severe combined immunodeficiency is a rare genetic disorder that is sometimes called “bubble baby disease” because individuals who have it are so vulnerable to infections that they must live in a sterile environment. Diagnosis of severe combined immunodeficiency in the first weeks of life provides a critical opportunity to protect children from persistent infections and to consider potentially curative bone marrow transplant or gene therapy.Yet despite the development of a successful screening test in 2008, and its addition to the Recommended Uniform Screening Panel in 2010, two states (Indiana and Louisiana) had not added it to their newborn screening programs as of March 2018 (see the chart below). Petition the advisory committee quickly. Even if the Advisory Committee on Heritable Disorders in Newborns and Children rejects a new test, going through the process will raise awareness to support re-nomination and provide valuable feedback for further development.Increase funding for test development and improvement. Increased funding from patient advocacy organizations, biopharmaceutical companies, and government sources to develop new tests, as well as investments that improve established newborn screening tests or reduce their cost, would speed the adoption of new tests and lead to earlier detection of genetic diseases while streamlining overall program costs, a major hurdle for many states.Newborn screening programs save lives, prevent serious injury to thousands of infants each year, and shield affected families from out-of-pocket costs. It’s time to take the responsibility for introducing new tests off the backs of affected families and physicians struggling to cope at the edges of modern medicine and ensure that children don’t suffer needlessly because they were born in the wrong state.Robert Moy is a principal at Clarion Healthcare, a life sciences consultancy whose clients include pharmaceutical and biotech companies. Seamus Levine-Wilkinson, Ph.D. is a manager at Clarion Healthcare. Joseph Sterk is an independent consultant and former diagnostics executive. Related: A baby with a disease gene or no baby at all: Genetic testing of embryos creates an ethical morass The lengthy process of approving and implementing a new test robs children, their parents, and health care providers of the chance to intervene early and prevent unnecessary suffering and damage.advertisement Seamus Levine-Wilkinson Robert Moy First OpinionDelays in adding new newborn screening tests harm babies, families Tags diagnosticspediatricsrare disease [email protected] Related:last_img read more

Want to get out of the house? There’s a range of great events around the county this St Stephen’s Day

first_img Previous articleGreat day promised in Coolrain for Clonenagh Tractor RunNext articleDamien Bowe to feature today on our Christmas Video Interview Series LaoisToday Reporter Charlie Flanagan on Electric Picnic: ‘I’d ask organisers to consult with community leaders’ WhatsApp Facebook Pinterest Pinterest Community Home Lifestyle Want to get out of the house? There’s a range of great… LifestyleOut and About Community Brought to you by Laois TourismYou’ve had the turkey and ham, probably a couple of drinks, a half a box of Roses and you’ve watched enough bad TV to do you until the New Year.Now it’s time to start thinking of getting out of the house.And there is an amount of events around the county today to keep you entertained. Many of them are exercise-based but they won’t be too hard on you.Ballyroan, Clonaslee, Durrow and Gathabawn are among the places that are hosting organised walks or runs.And we also have details of some of the live music on in Laois this evening.WEDNESDAY, DECEMBER 26Slieve Bloom Guided WalkThe Slieve Bloom Walking Club’s next guided walk is The Durrow Leafy Loops Walk.  This walk is a Grade B 14km walk and takes 4 hours so a good level of fitness is required.Meeting point is at Castle Arms Hotel at 11am.  €5 per walk or €20 annual membership.Ballyroan Abbey’s Annual St Stephens Day 5km RunWhy not join the annual St Stephen’s day 5k fun run where you can work off the Christmas dinner and swap Santa stories.Lots of prizes for adults and juvenile runners on the day with refreshments served after in the community hall.  Registration from 10.00 run begins at 11am sharp.Laois Hospice Annual St Stephen’s Day WalkJoin the annual mountain walk for Laois Hospice in Clonaslee on St Stephen’s day.  There will be 2 walks with the longer one beginning at 12 noon and the shorter one at 1pm.Registration is at the Clonaslee Community Centre before both walks. Sponsorship/ donations are requested on the day.Gathabawn Loop St Stephen’s Day WalkAnother annual charity walk and a great excuse to get out and about!  This year’s charities are Lisdowney Saint Vincent De Paul and Gathabawn Rural Development Group.  There are two loops, one is the full 12km and the shorter one is 7km.The walk begins at 12 noon and registration takes place at Mackey’s Bar from 11.30am.  Soup will be provided for all walkers at the end.The Jury – Live MusicAnother favourite play Kavanagh’s Bar & Venue St Stephen’s Night. There is no cover charge and the gig begins at 10pm.Kora GriffinKora Griffin is back in Sheeran’s Pub, Coolrain with live music from 10pm. There is no cover chargeSEE ALSO – Your full guide to What’s On in Laois this Christmas Facebookcenter_img WhatsApp New Arles road opens but disquiet over who was invited to official opening Twitter Want to get out of the house? There’s a range of great events around the county this St Stephen’s Day RELATED ARTICLESMORE FROM AUTHOR Laois secondary school announces scholarship winners for new academic year By LaoisToday Reporter – 26th December 2018 Twitter Council last_img read more